Tuesday, December 30, 2008

Caffeine and Melatonin

Here is an interesting study done by some folks at the University of Mainz in Germany.



The article is titled:
“Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity”

and can be found at:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1884289



Among other things, it states that, “caffeine was found to increase the oral bioavailability of melatonin”.

That makes sense I suppose. As far as I know, caffeine works by inhibiting adenosine, which is itself a type of “inhibitor”. So maybe adenosine or something
like it is also inhibiting melatonin? Hmmm…

That being said, the focus of this study was on the “oral bioavailability” of melatonin. Which, I assume, is talking about melatonin supplements. However, maybe caffeine has some effect on endogenous melatonin as well? I’m speculating here, and I’m way out of my field of knowledge, (liberal arts degree be damned) but hey why not?

At any rate, if indeed caffeine has an effect on increasing endogenous melatonin, (my probably, easy- to-prove-against-speculation) this would be quite the news. It would certainly give credence to all those miraculous individuals who are able to have a cup of coffee and then promptly fall asleep. It would also seem, that the key to utilizing caffeine for wakefulness is to use it with light!

On the other hand…if one is a regular coffee/caffeine user,
and would consequently have higher levels of adenosine,
then perhaps the higher adenosine levels would suppress melatonin and give the user a difficult time while trying to fall asleep. This might especially be the case if one only had caffeine early in the day.

For example, lets say coffee is gulped down in the morning, thereby suppressing adenosine levels. With its natural penchant for homeostasis, the body would respond by creating higher levels of adenosine. Over the course of the day, the caffeine will fade away and the adenosine will slowly creep back into place. Only by now, it is at much higher levels. By the time night comes, the higher levels of adenosine will be suppressing everything from adrenaline to melatonin. Thereby making the user both incredibly exhausted, yet somewhat of an insomniac. Which in turn probably leads to terrible sleep, a groggy morning and another cup of coffee.

But! If you had been taking coffee all day and keeping your adenosine levels low, then perhaps your melatonin levels might be at their normal proportions by bedtime. However, I’m not really sure of the speed at which all this is happening. Perhaps adenosine launches back at full strength far faster than I’m accounting for. In addition, if you were drinking caffeine all day you would have to deal with the other effects of adenosine suppression…namely higher levels of adrenaline!

Good grief, to think there is so much going on “under the hood” when you drink coffee and try to go to sleep. ☺

-R

Caffeine and Melatonin

Here is an interesting study done by some folks at the University of Mainz in Germany.



The article is titled:
“Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity”

and can be found at:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1884289



Among other things, it states that, “caffeine was found to increase the oral bioavailability of melatonin”.

That makes sense I suppose. As far as I know, caffeine works by inhibiting adenosine, which is itself a type of “inhibitor”. So maybe adenosine or something
like it is also inhibiting melatonin? Hmmm…

That being said, the focus of this study was on the “oral bioavailability” of melatonin. Which, I assume, is talking about melatonin supplements. However, maybe caffeine has some effect on endogenous melatonin as well? I’m speculating here, and I’m way out of my field of knowledge, (liberal arts degree be damned) but hey why not?

At any rate, if indeed caffeine has an effect on increasing endogenous melatonin, (my probably, easy- to-prove-against-speculation) this would be quite the news. It would certainly give credence to all those miraculous individuals who are able to have a cup of coffee and then promptly fall asleep. It would also seem, that the key to utilizing caffeine for wakefulness is to use it with light!

On the other hand…if one is a regular coffee/caffeine user,
and would consequently have higher levels of adenosine,
then perhaps the higher adenosine levels would suppress melatonin and give the user a difficult time while trying to fall asleep. This might especially be the case if one only had caffeine early in the day.

For example, lets say coffee is gulped down in the morning, thereby suppressing adenosine levels. With its natural penchant for homeostasis, the body would respond by creating higher levels of adenosine. Over the course of the day, the caffeine will fade away and the adenosine will slowly creep back into place. Only by now, it is at much higher levels. By the time night comes, the higher levels of adenosine will be suppressing everything from adrenaline to melatonin. Thereby making the user both incredibly exhausted, yet somewhat of an insomniac. Which in turn probably leads to terrible sleep, a groggy morning and another cup of coffee.

But! If you had been taking coffee all day and keeping your adenosine levels low, then perhaps your melatonin levels might be at their normal proportions by bedtime. However, I’m not really sure of the speed at which all this is happening. Perhaps adenosine launches back at full strength far faster than I’m accounting for. In addition, if you were drinking caffeine all day you would have to deal with the other effects of adenosine suppression…namely higher levels of adrenaline!

Good grief, to think there is so much going on “under the hood” when you drink coffee and try to go to sleep. ☺

-R

Caffeine and Melatonin

Here is an interesting study done by some folks at the University of Mainz in Germany.



The article is titled:
“Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity”

and can be found at:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1884289



Among other things, it states that, “caffeine was found to increase the oral bioavailability of melatonin”.

That makes sense I suppose. As far as I know, caffeine works by inhibiting adenosine, which is itself a type of “inhibitor”. So maybe adenosine or something
like it is also inhibiting melatonin? Hmmm…

That being said, the focus of this study was on the “oral bioavailability” of melatonin. Which, I assume, is talking about melatonin supplements. However, maybe caffeine has some effect on endogenous melatonin as well? I’m speculating here, and I’m way out of my field of knowledge, (liberal arts degree be damned) but hey why not?

At any rate, if indeed caffeine has an effect on increasing endogenous melatonin, (my probably, easy- to-prove-against-speculation) this would be quite the news. It would certainly give credence to all those miraculous individuals who are able to have a cup of coffee and then promptly fall asleep. It would also seem, that the key to utilizing caffeine for wakefulness is to use it with light!

On the other hand…if one is a regular coffee/caffeine user,
and would consequently have higher levels of adenosine,
then perhaps the higher adenosine levels would suppress melatonin and give the user a difficult time while trying to fall asleep. This might especially be the case if one only had caffeine early in the day.

For example, lets say coffee is gulped down in the morning, thereby suppressing adenosine levels. With its natural penchant for homeostasis, the body would respond by creating higher levels of adenosine. Over the course of the day, the caffeine will fade away and the adenosine will slowly creep back into place. Only by now, it is at much higher levels. By the time night comes, the higher levels of adenosine will be suppressing everything from adrenaline to melatonin. Thereby making the user both incredibly exhausted, yet somewhat of an insomniac. Which in turn probably leads to terrible sleep, a groggy morning and another cup of coffee.

But! If you had been taking coffee all day and keeping your adenosine levels low, then perhaps your melatonin levels might be at their normal proportions by bedtime. However, I’m not really sure of the speed at which all this is happening. Perhaps adenosine launches back at full strength far faster than I’m accounting for. In addition, if you were drinking caffeine all day you would have to deal with the other effects of adenosine suppression…namely higher levels of adrenaline!

Good grief, to think there is so much going on “under the hood” when you drink coffee and try to go to sleep. ☺

-R

Caffeine and Melatonin

Here is an interesting study done by some folks at the University of Mainz in Germany.



The article is titled:
“Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity”

and can be found at:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1884289



Among other things, it states that, “caffeine was found to increase the oral bioavailability of melatonin”.

That makes sense I suppose. As far as I know, caffeine works by inhibiting adenosine, which is itself a type of “inhibitor”. So maybe adenosine or something
like it is also inhibiting melatonin? Hmmm…

That being said, the focus of this study was on the “oral bioavailability” of melatonin. Which, I assume, is talking about melatonin supplements. However, maybe caffeine has some effect on endogenous melatonin as well? I’m speculating here, and I’m way out of my field of knowledge, (liberal arts degree be damned) but hey why not?

At any rate, if indeed caffeine has an effect on increasing endogenous melatonin, (my probably, easy- to-prove-against-speculation) this would be quite the news. It would certainly give credence to all those miraculous individuals who are able to have a cup of coffee and then promptly fall asleep. It would also seem, that the key to utilizing caffeine for wakefulness is to use it with light!

On the other hand…if one is a regular coffee/caffeine user,
and would consequently have higher levels of adenosine,
then perhaps the higher adenosine levels would suppress melatonin and give the user a difficult time while trying to fall asleep. This might especially be the case if one only had caffeine early in the day.

For example, lets say coffee is gulped down in the morning, thereby suppressing adenosine levels. With its natural penchant for homeostasis, the body would respond by creating higher levels of adenosine. Over the course of the day, the caffeine will fade away and the adenosine will slowly creep back into place. Only by now, it is at much higher levels. By the time night comes, the higher levels of adenosine will be suppressing everything from adrenaline to melatonin. Thereby making the user both incredibly exhausted, yet somewhat of an insomniac. Which in turn probably leads to terrible sleep, a groggy morning and another cup of coffee.

But! If you had been taking coffee all day and keeping your adenosine levels low, then perhaps your melatonin levels might be at their normal proportions by bedtime. However, I’m not really sure of the speed at which all this is happening. Perhaps adenosine launches back at full strength far faster than I’m accounting for. In addition, if you were drinking caffeine all day you would have to deal with the other effects of adenosine suppression…namely higher levels of adrenaline!

Good grief, to think there is so much going on “under the hood” when you drink coffee and try to go to sleep. ☺

-R

Callaway article

I’ve been trying to locate an article by J.C. Callaway regarding the possible role of DMT in dreams. Unfortunately, I have been unable to find a free .pdf version, so I think I may have to go to a library and request it via inter-library loan. At any rate, here is the citation for the article:

“A proposed mechanism for the visions of dream sleep” by J.C. Callaway
It is found in the journal Medical Hypotheses, Volume 26, Issue 2, June 1988, pages 119-124.

I think I see that you found the same article at ScienceDirect!
I will certainly post on here if I get a chance to read it.

In other J.C. Callaway news, I found him mentioned in a talk by Dennis McKenna on the C-realm podcast. Which may be located here:

http://www.archive.org/details/Episode39Part2TheThreePoundUniverse

It is the second part of the talk and I would highly recommend the first section as well. However, there is no mention of dreams.

-R

Callaway article

I’ve been trying to locate an article by J.C. Callaway regarding the possible role of DMT in dreams. Unfortunately, I have been unable to find a free .pdf version, so I think I may have to go to a library and request it via inter-library loan. At any rate, here is the citation for the article:

“A proposed mechanism for the visions of dream sleep” by J.C. Callaway
It is found in the journal Medical Hypotheses, Volume 26, Issue 2, June 1988, pages 119-124.

I think I see that you found the same article at ScienceDirect!
I will certainly post on here if I get a chance to read it.

In other J.C. Callaway news, I found him mentioned in a talk by Dennis McKenna on the C-realm podcast. Which may be located here:

http://www.archive.org/details/Episode39Part2TheThreePoundUniverse

It is the second part of the talk and I would highly recommend the first section as well. However, there is no mention of dreams.

-R

Callaway article

I’ve been trying to locate an article by J.C. Callaway regarding the possible role of DMT in dreams. Unfortunately, I have been unable to find a free .pdf version, so I think I may have to go to a library and request it via inter-library loan. At any rate, here is the citation for the article:

“A proposed mechanism for the visions of dream sleep” by J.C. Callaway
It is found in the journal Medical Hypotheses, Volume 26, Issue 2, June 1988, pages 119-124.

I think I see that you found the same article at ScienceDirect!
I will certainly post on here if I get a chance to read it.

In other J.C. Callaway news, I found him mentioned in a talk by Dennis McKenna on the C-realm podcast. Which may be located here:

http://www.archive.org/details/Episode39Part2TheThreePoundUniverse

It is the second part of the talk and I would highly recommend the first section as well. However, there is no mention of dreams.

-R

Callaway article

I’ve been trying to locate an article by J.C. Callaway regarding the possible role of DMT in dreams. Unfortunately, I have been unable to find a free .pdf version, so I think I may have to go to a library and request it via inter-library loan. At any rate, here is the citation for the article:

“A proposed mechanism for the visions of dream sleep” by J.C. Callaway
It is found in the journal Medical Hypotheses, Volume 26, Issue 2, June 1988, pages 119-124.

I think I see that you found the same article at ScienceDirect!
I will certainly post on here if I get a chance to read it.

In other J.C. Callaway news, I found him mentioned in a talk by Dennis McKenna on the C-realm podcast. Which may be located here:

http://www.archive.org/details/Episode39Part2TheThreePoundUniverse

It is the second part of the talk and I would highly recommend the first section as well. However, there is no mention of dreams.

-R

Up Late and Reply of Dr. Strassman

I have been reading around trying to find a relationship with some plants that help dream recall and lucid dreaming and serotonin or choline. I found some good references but its getting late and I have been unable to find any info.

I did happen to find a lot of information on l-Tryptophan and its relationship to many different types of DMT found in the human body. It seems that 5-HP, and MAOI's cause the creation of DMT inside of the brain. It is still unknown where DMT is located, but it would seem that the pineal gland still is a good place to have DMT made. Though there may not be a build up of DMT in the body, making it hard to locate, there may be a buildup of a combination of chemicals that once released and mixed together in the cerebrospinal fluid of the brain molds the DMT and displaces it into the brain evenly.

I am also posting my e-mail conversation with Dr. Strassman to maybe explain some questions:

After reading your book I had a question about the types of chemicals
that you talked about that existed in the pineal gland that you said
have the possibility to create DMT such as the methyltransferaes and
beta-carbolines. I was wondering how you found this information. I
also wanted to know the relationship of melatonin and DMT. I have
asked my friend the same questions and though he is not a chemists he
described to me that the melatonin may increase along with all the
other chemicals that you talked about in the pineal gland causing a
possible increase of DMT during night hours. I still don't see the
relationship of melatonin in the pineal besides to put the person to
sleep since in your studies you have showed that melatonin has little
to no psychedelic effects.

I have not read any new information on studies done to find out if the
theories of the pineal gland producing DMT being true. It seems that
in 28 years since your study, someone would have done something since
then into finding out the facts of the pineal gland. If you have any
journals that show these types of studies it would be helpful for my
research.

Pinoline is a beta-carboline Jace Callaway described finding in pineal. Methytransferases exist in pineal, particularly hydroxy-indole-N-methyltransferase, which is the enzyme finalizing melatonin production. It's in the literature.

Melatonin increases at night, in darkness. We don't know anything about a pineal-DMT connection. The evidence I marshal is circumstantial. I didn't make that clear enough in my book.

Melatonin is not psychedelic, correct.

Not quite 28 years - I wrapped up my psychedelic research in 1995, published my earlier melatonin data in the late 80's.


Here is my references I used for the night:

Here are the plant references:

Bouncing Bear Botanicals. (2008). Calea zacatechichi (Dream Herb, Leaf of God). Retrieved on Sept 28, 2008 from http://www.bouncingbearbotanicals.com/dream-herb-p-100.html

Mayagoitia, L., J. Diaz, C.M. Contreras. (1986). Psychopharmacologic Analysis of an Alleged Oneirogenic Plant: Calea zacatechichi. Journal of Ethnopharmacology. 18:229-243. Retrieved on Sept 28, 2008 from http://leda.lycaeum.org/?ID=16295

Psychoactiveherbs (2008). African Dream Root, Silene capensis (Ubulawu). Retrieved on Sept 28, 2008 from http://psychoactiveherbs.com/catalog/index.php?cPath=161_158

Sobiecki, J.F. (2008). A Review of Plants Used in Divination in South Afreica. Department of Anthropology and Development Studies, Rand Afrikaans University, South Africa. Retrieved on Sept 28, 2008 from http://www.wits.ac.za/izangoma/visionsynthesis26.pdf

http://sleep-disorders.suite101.com/article.cfm/how_drugs_and_herbs_affect_dreams

Here are addition references on endogenous psychedelics:

http://jpet.aspetjournals.org/cgi/content/abstract/185/3/523
http://everything2.com/title/tryptamine
http://209.85.173.132/search?q=cache:ZnTEcIEf_7kJ:psychicdeli.googlepages.com/Sacramentalplantsandpsi-Brazil2008.doc+Endogenous+psychedelics&hl=en&ct=clnk&cd=9&gl=us&client=firefox-a
http://www.maps.org/news-letters/v04n2/04230cal.html

Up Late and Reply of Dr. Strassman

I have been reading around trying to find a relationship with some plants that help dream recall and lucid dreaming and serotonin or choline. I found some good references but its getting late and I have been unable to find any info.

I did happen to find a lot of information on l-Tryptophan and its relationship to many different types of DMT found in the human body. It seems that 5-HP, and MAOI's cause the creation of DMT inside of the brain. It is still unknown where DMT is located, but it would seem that the pineal gland still is a good place to have DMT made. Though there may not be a build up of DMT in the body, making it hard to locate, there may be a buildup of a combination of chemicals that once released and mixed together in the cerebrospinal fluid of the brain molds the DMT and displaces it into the brain evenly.

I am also posting my e-mail conversation with Dr. Strassman to maybe explain some questions:

After reading your book I had a question about the types of chemicals
that you talked about that existed in the pineal gland that you said
have the possibility to create DMT such as the methyltransferaes and
beta-carbolines. I was wondering how you found this information. I
also wanted to know the relationship of melatonin and DMT. I have
asked my friend the same questions and though he is not a chemists he
described to me that the melatonin may increase along with all the
other chemicals that you talked about in the pineal gland causing a
possible increase of DMT during night hours. I still don't see the
relationship of melatonin in the pineal besides to put the person to
sleep since in your studies you have showed that melatonin has little
to no psychedelic effects.

I have not read any new information on studies done to find out if the
theories of the pineal gland producing DMT being true. It seems that
in 28 years since your study, someone would have done something since
then into finding out the facts of the pineal gland. If you have any
journals that show these types of studies it would be helpful for my
research.

Pinoline is a beta-carboline Jace Callaway described finding in pineal. Methytransferases exist in pineal, particularly hydroxy-indole-N-methyltransferase, which is the enzyme finalizing melatonin production. It's in the literature.

Melatonin increases at night, in darkness. We don't know anything about a pineal-DMT connection. The evidence I marshal is circumstantial. I didn't make that clear enough in my book.

Melatonin is not psychedelic, correct.

Not quite 28 years - I wrapped up my psychedelic research in 1995, published my earlier melatonin data in the late 80's.


Here is my references I used for the night:

Here are the plant references:

Bouncing Bear Botanicals. (2008). Calea zacatechichi (Dream Herb, Leaf of God). Retrieved on Sept 28, 2008 from http://www.bouncingbearbotanicals.com/dream-herb-p-100.html

Mayagoitia, L., J. Diaz, C.M. Contreras. (1986). Psychopharmacologic Analysis of an Alleged Oneirogenic Plant: Calea zacatechichi. Journal of Ethnopharmacology. 18:229-243. Retrieved on Sept 28, 2008 from http://leda.lycaeum.org/?ID=16295

Psychoactiveherbs (2008). African Dream Root, Silene capensis (Ubulawu). Retrieved on Sept 28, 2008 from http://psychoactiveherbs.com/catalog/index.php?cPath=161_158

Sobiecki, J.F. (2008). A Review of Plants Used in Divination in South Afreica. Department of Anthropology and Development Studies, Rand Afrikaans University, South Africa. Retrieved on Sept 28, 2008 from http://www.wits.ac.za/izangoma/visionsynthesis26.pdf

http://sleep-disorders.suite101.com/article.cfm/how_drugs_and_herbs_affect_dreams

Here are addition references on endogenous psychedelics:

http://jpet.aspetjournals.org/cgi/content/abstract/185/3/523
http://everything2.com/title/tryptamine
http://209.85.173.132/search?q=cache:ZnTEcIEf_7kJ:psychicdeli.googlepages.com/Sacramentalplantsandpsi-Brazil2008.doc+Endogenous+psychedelics&hl=en&ct=clnk&cd=9&gl=us&client=firefox-a
http://www.maps.org/news-letters/v04n2/04230cal.html

Up Late and Reply of Dr. Strassman

I have been reading around trying to find a relationship with some plants that help dream recall and lucid dreaming and serotonin or choline. I found some good references but its getting late and I have been unable to find any info.

I did happen to find a lot of information on l-Tryptophan and its relationship to many different types of DMT found in the human body. It seems that 5-HP, and MAOI's cause the creation of DMT inside of the brain. It is still unknown where DMT is located, but it would seem that the pineal gland still is a good place to have DMT made. Though there may not be a build up of DMT in the body, making it hard to locate, there may be a buildup of a combination of chemicals that once released and mixed together in the cerebrospinal fluid of the brain molds the DMT and displaces it into the brain evenly.

I am also posting my e-mail conversation with Dr. Strassman to maybe explain some questions:

After reading your book I had a question about the types of chemicals
that you talked about that existed in the pineal gland that you said
have the possibility to create DMT such as the methyltransferaes and
beta-carbolines. I was wondering how you found this information. I
also wanted to know the relationship of melatonin and DMT. I have
asked my friend the same questions and though he is not a chemists he
described to me that the melatonin may increase along with all the
other chemicals that you talked about in the pineal gland causing a
possible increase of DMT during night hours. I still don't see the
relationship of melatonin in the pineal besides to put the person to
sleep since in your studies you have showed that melatonin has little
to no psychedelic effects.

I have not read any new information on studies done to find out if the
theories of the pineal gland producing DMT being true. It seems that
in 28 years since your study, someone would have done something since
then into finding out the facts of the pineal gland. If you have any
journals that show these types of studies it would be helpful for my
research.

Pinoline is a beta-carboline Jace Callaway described finding in pineal. Methytransferases exist in pineal, particularly hydroxy-indole-N-methyltransferase, which is the enzyme finalizing melatonin production. It's in the literature.

Melatonin increases at night, in darkness. We don't know anything about a pineal-DMT connection. The evidence I marshal is circumstantial. I didn't make that clear enough in my book.

Melatonin is not psychedelic, correct.

Not quite 28 years - I wrapped up my psychedelic research in 1995, published my earlier melatonin data in the late 80's.


Here is my references I used for the night:

Here are the plant references:

Bouncing Bear Botanicals. (2008). Calea zacatechichi (Dream Herb, Leaf of God). Retrieved on Sept 28, 2008 from http://www.bouncingbearbotanicals.com/dream-herb-p-100.html

Mayagoitia, L., J. Diaz, C.M. Contreras. (1986). Psychopharmacologic Analysis of an Alleged Oneirogenic Plant: Calea zacatechichi. Journal of Ethnopharmacology. 18:229-243. Retrieved on Sept 28, 2008 from http://leda.lycaeum.org/?ID=16295

Psychoactiveherbs (2008). African Dream Root, Silene capensis (Ubulawu). Retrieved on Sept 28, 2008 from http://psychoactiveherbs.com/catalog/index.php?cPath=161_158

Sobiecki, J.F. (2008). A Review of Plants Used in Divination in South Afreica. Department of Anthropology and Development Studies, Rand Afrikaans University, South Africa. Retrieved on Sept 28, 2008 from http://www.wits.ac.za/izangoma/visionsynthesis26.pdf

http://sleep-disorders.suite101.com/article.cfm/how_drugs_and_herbs_affect_dreams

Here are addition references on endogenous psychedelics:

http://jpet.aspetjournals.org/cgi/content/abstract/185/3/523
http://everything2.com/title/tryptamine
http://209.85.173.132/search?q=cache:ZnTEcIEf_7kJ:psychicdeli.googlepages.com/Sacramentalplantsandpsi-Brazil2008.doc+Endogenous+psychedelics&hl=en&ct=clnk&cd=9&gl=us&client=firefox-a
http://www.maps.org/news-letters/v04n2/04230cal.html

Up Late and Reply of Dr. Strassman

I have been reading around trying to find a relationship with some plants that help dream recall and lucid dreaming and serotonin or choline. I found some good references but its getting late and I have been unable to find any info.

I did happen to find a lot of information on l-Tryptophan and its relationship to many different types of DMT found in the human body. It seems that 5-HP, and MAOI's cause the creation of DMT inside of the brain. It is still unknown where DMT is located, but it would seem that the pineal gland still is a good place to have DMT made. Though there may not be a build up of DMT in the body, making it hard to locate, there may be a buildup of a combination of chemicals that once released and mixed together in the cerebrospinal fluid of the brain molds the DMT and displaces it into the brain evenly.

I am also posting my e-mail conversation with Dr. Strassman to maybe explain some questions:

After reading your book I had a question about the types of chemicals
that you talked about that existed in the pineal gland that you said
have the possibility to create DMT such as the methyltransferaes and
beta-carbolines. I was wondering how you found this information. I
also wanted to know the relationship of melatonin and DMT. I have
asked my friend the same questions and though he is not a chemists he
described to me that the melatonin may increase along with all the
other chemicals that you talked about in the pineal gland causing a
possible increase of DMT during night hours. I still don't see the
relationship of melatonin in the pineal besides to put the person to
sleep since in your studies you have showed that melatonin has little
to no psychedelic effects.

I have not read any new information on studies done to find out if the
theories of the pineal gland producing DMT being true. It seems that
in 28 years since your study, someone would have done something since
then into finding out the facts of the pineal gland. If you have any
journals that show these types of studies it would be helpful for my
research.

Pinoline is a beta-carboline Jace Callaway described finding in pineal. Methytransferases exist in pineal, particularly hydroxy-indole-N-methyltransferase, which is the enzyme finalizing melatonin production. It's in the literature.

Melatonin increases at night, in darkness. We don't know anything about a pineal-DMT connection. The evidence I marshal is circumstantial. I didn't make that clear enough in my book.

Melatonin is not psychedelic, correct.

Not quite 28 years - I wrapped up my psychedelic research in 1995, published my earlier melatonin data in the late 80's.


Here is my references I used for the night:

Here are the plant references:

Bouncing Bear Botanicals. (2008). Calea zacatechichi (Dream Herb, Leaf of God). Retrieved on Sept 28, 2008 from http://www.bouncingbearbotanicals.com/dream-herb-p-100.html

Mayagoitia, L., J. Diaz, C.M. Contreras. (1986). Psychopharmacologic Analysis of an Alleged Oneirogenic Plant: Calea zacatechichi. Journal of Ethnopharmacology. 18:229-243. Retrieved on Sept 28, 2008 from http://leda.lycaeum.org/?ID=16295

Psychoactiveherbs (2008). African Dream Root, Silene capensis (Ubulawu). Retrieved on Sept 28, 2008 from http://psychoactiveherbs.com/catalog/index.php?cPath=161_158

Sobiecki, J.F. (2008). A Review of Plants Used in Divination in South Afreica. Department of Anthropology and Development Studies, Rand Afrikaans University, South Africa. Retrieved on Sept 28, 2008 from http://www.wits.ac.za/izangoma/visionsynthesis26.pdf

http://sleep-disorders.suite101.com/article.cfm/how_drugs_and_herbs_affect_dreams

Here are addition references on endogenous psychedelics:

http://jpet.aspetjournals.org/cgi/content/abstract/185/3/523
http://everything2.com/title/tryptamine
http://209.85.173.132/search?q=cache:ZnTEcIEf_7kJ:psychicdeli.googlepages.com/Sacramentalplantsandpsi-Brazil2008.doc+Endogenous+psychedelics&hl=en&ct=clnk&cd=9&gl=us&client=firefox-a
http://www.maps.org/news-letters/v04n2/04230cal.html

Sunday, December 28, 2008

Info

I did what we talked about tonight and put my notes from the books we read into draft sections so that they don't get posted on the internet. I will still post the books I have read in the future, just not all the notes.

Here is some of the links including what you posted.

Is the DMT/dreaming connection bullshit? - dmt - tribe.net

Stress, Sports and Performance

Cottonwood Research Foundation -> Ongoing Projects

Drugs and Society - Google Book Search

NationMaster - Encyclopedia: Myristicin

Proton and carbon-13 NMR studies of some tryptamines, precursors, and derivatives : Ab initio calculations for optimized structures

Dr. Albert Hofmann | Psilocybin | Psilocin
Dr. Albert Hofmann
ScienceDirect - Medical Hypotheses : A proposed mechanism for the visions of dream sleep

The Pineal Gland, LSD, and Serotonin — Updated: October 15, 1996

Joseph C. Callaway, Ph.D.

The Entheogenic Evolution
Welcome to the Entheogenic Evolution Podcast, hosted by author Martin W. Ball, Ph.D. This podcast is dedicated to the discussion of the responsible and spiritual use of entheogens as agents of personal transformation and evolution. As sacred tools, etheogens have the power to "awaken the divine within" and bring us closer to our connection with the Sacred and with Spirit. For all those who walk the path of plant-based medicine and spiritual enlightenment . . . enjoy!PodOmatic podcast portal: Create, Find, Share Podcasts! Get your free podcast hosting, free podcast creation, podcasting tips, free podcast tools, free service for podcasters, podcast software, best podcasts, podcasting news, new podcast feeds, top ten podcasts, learn how to podcast, podcasting forum for the podcast community
Episode 39 - Part 1: The Three Pound Universe
Discussions on topics focused on the coming Vingean Singularity, Entheogenic Exploration, the re-localization of community & agriculture, and Individual Conscious Autonomy.PodOmatic podcast portal: Create, Find, Share Podcasts! Get your free podcast hosting, free podcast creation, podcasting tips, free podcast tools, free service for podcasters, podcast software, best podcasts, podcasting news, new podcast feeds, top ten podcasts, learn how to podcast, podcasting forum for the podcast community



-L

Info

I did what we talked about tonight and put my notes from the books we read into draft sections so that they don't get posted on the internet. I will still post the books I have read in the future, just not all the notes.

Here is some of the links including what you posted.

Is the DMT/dreaming connection bullshit? - dmt - tribe.net

Stress, Sports and Performance

Cottonwood Research Foundation -> Ongoing Projects

Drugs and Society - Google Book Search

NationMaster - Encyclopedia: Myristicin

Proton and carbon-13 NMR studies of some tryptamines, precursors, and derivatives : Ab initio calculations for optimized structures

Dr. Albert Hofmann | Psilocybin | Psilocin
Dr. Albert Hofmann
ScienceDirect - Medical Hypotheses : A proposed mechanism for the visions of dream sleep

The Pineal Gland, LSD, and Serotonin — Updated: October 15, 1996

Joseph C. Callaway, Ph.D.

The Entheogenic Evolution
Welcome to the Entheogenic Evolution Podcast, hosted by author Martin W. Ball, Ph.D. This podcast is dedicated to the discussion of the responsible and spiritual use of entheogens as agents of personal transformation and evolution. As sacred tools, etheogens have the power to "awaken the divine within" and bring us closer to our connection with the Sacred and with Spirit. For all those who walk the path of plant-based medicine and spiritual enlightenment . . . enjoy!PodOmatic podcast portal: Create, Find, Share Podcasts! Get your free podcast hosting, free podcast creation, podcasting tips, free podcast tools, free service for podcasters, podcast software, best podcasts, podcasting news, new podcast feeds, top ten podcasts, learn how to podcast, podcasting forum for the podcast community
Episode 39 - Part 1: The Three Pound Universe
Discussions on topics focused on the coming Vingean Singularity, Entheogenic Exploration, the re-localization of community & agriculture, and Individual Conscious Autonomy.PodOmatic podcast portal: Create, Find, Share Podcasts! Get your free podcast hosting, free podcast creation, podcasting tips, free podcast tools, free service for podcasters, podcast software, best podcasts, podcasting news, new podcast feeds, top ten podcasts, learn how to podcast, podcasting forum for the podcast community



-L

Info

I did what we talked about tonight and put my notes from the books we read into draft sections so that they don't get posted on the internet. I will still post the books I have read in the future, just not all the notes.

Here is some of the links including what you posted.

Is the DMT/dreaming connection bullshit? - dmt - tribe.net

Stress, Sports and Performance

Cottonwood Research Foundation -> Ongoing Projects

Drugs and Society - Google Book Search

NationMaster - Encyclopedia: Myristicin

Proton and carbon-13 NMR studies of some tryptamines, precursors, and derivatives : Ab initio calculations for optimized structures

Dr. Albert Hofmann | Psilocybin | Psilocin
Dr. Albert Hofmann
ScienceDirect - Medical Hypotheses : A proposed mechanism for the visions of dream sleep

The Pineal Gland, LSD, and Serotonin — Updated: October 15, 1996

Joseph C. Callaway, Ph.D.

The Entheogenic Evolution
Welcome to the Entheogenic Evolution Podcast, hosted by author Martin W. Ball, Ph.D. This podcast is dedicated to the discussion of the responsible and spiritual use of entheogens as agents of personal transformation and evolution. As sacred tools, etheogens have the power to "awaken the divine within" and bring us closer to our connection with the Sacred and with Spirit. For all those who walk the path of plant-based medicine and spiritual enlightenment . . . enjoy!PodOmatic podcast portal: Create, Find, Share Podcasts! Get your free podcast hosting, free podcast creation, podcasting tips, free podcast tools, free service for podcasters, podcast software, best podcasts, podcasting news, new podcast feeds, top ten podcasts, learn how to podcast, podcasting forum for the podcast community
Episode 39 - Part 1: The Three Pound Universe
Discussions on topics focused on the coming Vingean Singularity, Entheogenic Exploration, the re-localization of community & agriculture, and Individual Conscious Autonomy.PodOmatic podcast portal: Create, Find, Share Podcasts! Get your free podcast hosting, free podcast creation, podcasting tips, free podcast tools, free service for podcasters, podcast software, best podcasts, podcasting news, new podcast feeds, top ten podcasts, learn how to podcast, podcasting forum for the podcast community



-L

Info

I did what we talked about tonight and put my notes from the books we read into draft sections so that they don't get posted on the internet. I will still post the books I have read in the future, just not all the notes.

Here is some of the links including what you posted.

Is the DMT/dreaming connection bullshit? - dmt - tribe.net

Stress, Sports and Performance

Cottonwood Research Foundation -> Ongoing Projects

Drugs and Society - Google Book Search

NationMaster - Encyclopedia: Myristicin

Proton and carbon-13 NMR studies of some tryptamines, precursors, and derivatives : Ab initio calculations for optimized structures

Dr. Albert Hofmann | Psilocybin | Psilocin
Dr. Albert Hofmann
ScienceDirect - Medical Hypotheses : A proposed mechanism for the visions of dream sleep

The Pineal Gland, LSD, and Serotonin — Updated: October 15, 1996

Joseph C. Callaway, Ph.D.

The Entheogenic Evolution
Welcome to the Entheogenic Evolution Podcast, hosted by author Martin W. Ball, Ph.D. This podcast is dedicated to the discussion of the responsible and spiritual use of entheogens as agents of personal transformation and evolution. As sacred tools, etheogens have the power to "awaken the divine within" and bring us closer to our connection with the Sacred and with Spirit. For all those who walk the path of plant-based medicine and spiritual enlightenment . . . enjoy!PodOmatic podcast portal: Create, Find, Share Podcasts! Get your free podcast hosting, free podcast creation, podcasting tips, free podcast tools, free service for podcasters, podcast software, best podcasts, podcasting news, new podcast feeds, top ten podcasts, learn how to podcast, podcasting forum for the podcast community
Episode 39 - Part 1: The Three Pound Universe
Discussions on topics focused on the coming Vingean Singularity, Entheogenic Exploration, the re-localization of community & agriculture, and Individual Conscious Autonomy.PodOmatic podcast portal: Create, Find, Share Podcasts! Get your free podcast hosting, free podcast creation, podcasting tips, free podcast tools, free service for podcasters, podcast software, best podcasts, podcasting news, new podcast feeds, top ten podcasts, learn how to podcast, podcasting forum for the podcast community



-L

Tuesday, December 16, 2008

Sleepless Night

The night before last night I took the combination of 5-HTP and Galantamine in order to try to obtain lucid dreaming but once again had no luck. I did happen to have intense dreams where I was overcoming some type of problem and the dreams were very rewarding during the waking day. Again last night I decided that maybe I just wasn't getting the right about of REM time in order to obtain the lucid dreaming I wanted to. What better way to do this than to induce more Choline into my system? I took Galantamine and Choline without the 5-HTP once again a second night before I went to bed. It was very hard to get to bed but when I did, the night was filled with interesting affects.

Finally fell asleep around 12:00 AM

About 1:00 AM felt like I should get up and get ready for my day.

About 2:30 had vibration effect where I finally was able to relax to the point that I fell into lucid state. I thought I was awake so I walked over to my bathroom and looked in the mirror. Everything was blurry and greenish. I walked down to the bottom of my stairs and moved shoes around in order to prove how awake I was. I walked outside and looked up into the sky seeing that it was full of stars and different planets. I decided that I was going to fly into them to see if I was dreaming or not. I flew faster than I could control and was soon into another galaxy and lost. I managed to find my way back where I got into my car and though still scared that I was somehow sleep walking started the car with no key. I drove around the block and a lot of other unimportant stuff happened. I soon after woke up.

About 4:50 had the dweller effect happen where it was the green goblin yelling die, soon woke up in panic.


Conclusion:
Though I did have the desired effect of obtaining lucid dreaming and the dweller effect, my night was filled with uneasy and non-satisfactory sleep. I never obtained the deep sleep that is needed for restfulness during the night while my night was flooded with constant REM sleep causing masses of dreaming. I would not recommend trying this system unless having another day to rest after the restless night to reclaim the much needed deep sleep missed out.

I also provided evidence into the aspect of OBE in the fact that I encountered all the same events that someone who supposedly has OBE, noticing the realness of my house in the dream, and I must say that it was one of the most vivid lucid dreams I have ever had, however; it was still incredibly fake once exploring outside areas showing that it was only a dream. I tend to rely on science as always and provide more evidence in supporting the fact that OBE are only extremely vivid conscious dreams obtained by means of the conscious transformation between non-REM to REM Sleep.

-L

Sleepless Night

The night before last night I took the combination of 5-HTP and Galantamine in order to try to obtain lucid dreaming but once again had no luck. I did happen to have intense dreams where I was overcoming some type of problem and the dreams were very rewarding during the waking day. Again last night I decided that maybe I just wasn't getting the right about of REM time in order to obtain the lucid dreaming I wanted to. What better way to do this than to induce more Choline into my system? I took Galantamine and Choline without the 5-HTP once again a second night before I went to bed. It was very hard to get to bed but when I did, the night was filled with interesting affects.

Finally fell asleep around 12:00 AM

About 1:00 AM felt like I should get up and get ready for my day.

About 2:30 had vibration effect where I finally was able to relax to the point that I fell into lucid state. I thought I was awake so I walked over to my bathroom and looked in the mirror. Everything was blurry and greenish. I walked down to the bottom of my stairs and moved shoes around in order to prove how awake I was. I walked outside and looked up into the sky seeing that it was full of stars and different planets. I decided that I was going to fly into them to see if I was dreaming or not. I flew faster than I could control and was soon into another galaxy and lost. I managed to find my way back where I got into my car and though still scared that I was somehow sleep walking started the car with no key. I drove around the block and a lot of other unimportant stuff happened. I soon after woke up.

About 4:50 had the dweller effect happen where it was the green goblin yelling die, soon woke up in panic.


Conclusion:
Though I did have the desired effect of obtaining lucid dreaming and the dweller effect, my night was filled with uneasy and non-satisfactory sleep. I never obtained the deep sleep that is needed for restfulness during the night while my night was flooded with constant REM sleep causing masses of dreaming. I would not recommend trying this system unless having another day to rest after the restless night to reclaim the much needed deep sleep missed out.

I also provided evidence into the aspect of OBE in the fact that I encountered all the same events that someone who supposedly has OBE, noticing the realness of my house in the dream, and I must say that it was one of the most vivid lucid dreams I have ever had, however; it was still incredibly fake once exploring outside areas showing that it was only a dream. I tend to rely on science as always and provide more evidence in supporting the fact that OBE are only extremely vivid conscious dreams obtained by means of the conscious transformation between non-REM to REM Sleep.

-L

Sleepless Night

The night before last night I took the combination of 5-HTP and Galantamine in order to try to obtain lucid dreaming but once again had no luck. I did happen to have intense dreams where I was overcoming some type of problem and the dreams were very rewarding during the waking day. Again last night I decided that maybe I just wasn't getting the right about of REM time in order to obtain the lucid dreaming I wanted to. What better way to do this than to induce more Choline into my system? I took Galantamine and Choline without the 5-HTP once again a second night before I went to bed. It was very hard to get to bed but when I did, the night was filled with interesting affects.

Finally fell asleep around 12:00 AM

About 1:00 AM felt like I should get up and get ready for my day.

About 2:30 had vibration effect where I finally was able to relax to the point that I fell into lucid state. I thought I was awake so I walked over to my bathroom and looked in the mirror. Everything was blurry and greenish. I walked down to the bottom of my stairs and moved shoes around in order to prove how awake I was. I walked outside and looked up into the sky seeing that it was full of stars and different planets. I decided that I was going to fly into them to see if I was dreaming or not. I flew faster than I could control and was soon into another galaxy and lost. I managed to find my way back where I got into my car and though still scared that I was somehow sleep walking started the car with no key. I drove around the block and a lot of other unimportant stuff happened. I soon after woke up.

About 4:50 had the dweller effect happen where it was the green goblin yelling die, soon woke up in panic.


Conclusion:
Though I did have the desired effect of obtaining lucid dreaming and the dweller effect, my night was filled with uneasy and non-satisfactory sleep. I never obtained the deep sleep that is needed for restfulness during the night while my night was flooded with constant REM sleep causing masses of dreaming. I would not recommend trying this system unless having another day to rest after the restless night to reclaim the much needed deep sleep missed out.

I also provided evidence into the aspect of OBE in the fact that I encountered all the same events that someone who supposedly has OBE, noticing the realness of my house in the dream, and I must say that it was one of the most vivid lucid dreams I have ever had, however; it was still incredibly fake once exploring outside areas showing that it was only a dream. I tend to rely on science as always and provide more evidence in supporting the fact that OBE are only extremely vivid conscious dreams obtained by means of the conscious transformation between non-REM to REM Sleep.

-L

Sleepless Night

The night before last night I took the combination of 5-HTP and Galantamine in order to try to obtain lucid dreaming but once again had no luck. I did happen to have intense dreams where I was overcoming some type of problem and the dreams were very rewarding during the waking day. Again last night I decided that maybe I just wasn't getting the right about of REM time in order to obtain the lucid dreaming I wanted to. What better way to do this than to induce more Choline into my system? I took Galantamine and Choline without the 5-HTP once again a second night before I went to bed. It was very hard to get to bed but when I did, the night was filled with interesting affects.

Finally fell asleep around 12:00 AM

About 1:00 AM felt like I should get up and get ready for my day.

About 2:30 had vibration effect where I finally was able to relax to the point that I fell into lucid state. I thought I was awake so I walked over to my bathroom and looked in the mirror. Everything was blurry and greenish. I walked down to the bottom of my stairs and moved shoes around in order to prove how awake I was. I walked outside and looked up into the sky seeing that it was full of stars and different planets. I decided that I was going to fly into them to see if I was dreaming or not. I flew faster than I could control and was soon into another galaxy and lost. I managed to find my way back where I got into my car and though still scared that I was somehow sleep walking started the car with no key. I drove around the block and a lot of other unimportant stuff happened. I soon after woke up.

About 4:50 had the dweller effect happen where it was the green goblin yelling die, soon woke up in panic.


Conclusion:
Though I did have the desired effect of obtaining lucid dreaming and the dweller effect, my night was filled with uneasy and non-satisfactory sleep. I never obtained the deep sleep that is needed for restfulness during the night while my night was flooded with constant REM sleep causing masses of dreaming. I would not recommend trying this system unless having another day to rest after the restless night to reclaim the much needed deep sleep missed out.

I also provided evidence into the aspect of OBE in the fact that I encountered all the same events that someone who supposedly has OBE, noticing the realness of my house in the dream, and I must say that it was one of the most vivid lucid dreams I have ever had, however; it was still incredibly fake once exploring outside areas showing that it was only a dream. I tend to rely on science as always and provide more evidence in supporting the fact that OBE are only extremely vivid conscious dreams obtained by means of the conscious transformation between non-REM to REM Sleep.

-L

Wednesday, December 10, 2008

The New Science of Dreaming

I will be adding more to this later but I wanted to post something that I found interesting that I read before I forgot.

SRM (Sleep-Related Mentation

SRM refers to any perceptual or mental state that occurs in temporal relation to some sleep process or state. IN humans we call some forms of SRM "dreams," where "dreams" refer to extended experiences of emotion laden imagery structured into story-like action episodes typically concerning the dreamer and his/her socially significant others. Many SRMs, however, are not dreams. Instead, they may be classified as hypnagogic images or fleeting and isolated though fragments, ongoing ruminations, verbalization's, or all manner of other types of mentation.

-L

The New Science of Dreaming

I will be adding more to this later but I wanted to post something that I found interesting that I read before I forgot.

SRM (Sleep-Related Mentation

SRM refers to any perceptual or mental state that occurs in temporal relation to some sleep process or state. IN humans we call some forms of SRM "dreams," where "dreams" refer to extended experiences of emotion laden imagery structured into story-like action episodes typically concerning the dreamer and his/her socially significant others. Many SRMs, however, are not dreams. Instead, they may be classified as hypnagogic images or fleeting and isolated though fragments, ongoing ruminations, verbalization's, or all manner of other types of mentation.

-L

The New Science of Dreaming

I will be adding more to this later but I wanted to post something that I found interesting that I read before I forgot.

SRM (Sleep-Related Mentation

SRM refers to any perceptual or mental state that occurs in temporal relation to some sleep process or state. IN humans we call some forms of SRM "dreams," where "dreams" refer to extended experiences of emotion laden imagery structured into story-like action episodes typically concerning the dreamer and his/her socially significant others. Many SRMs, however, are not dreams. Instead, they may be classified as hypnagogic images or fleeting and isolated though fragments, ongoing ruminations, verbalization's, or all manner of other types of mentation.

-L

The New Science of Dreaming

I will be adding more to this later but I wanted to post something that I found interesting that I read before I forgot.

SRM (Sleep-Related Mentation

SRM refers to any perceptual or mental state that occurs in temporal relation to some sleep process or state. IN humans we call some forms of SRM "dreams," where "dreams" refer to extended experiences of emotion laden imagery structured into story-like action episodes typically concerning the dreamer and his/her socially significant others. Many SRMs, however, are not dreams. Instead, they may be classified as hypnagogic images or fleeting and isolated though fragments, ongoing ruminations, verbalization's, or all manner of other types of mentation.

-L

Dream Study

So my proposal for a dream study was accepted by the psychology department adviser for this upcoming semester. It should be interesting and full of new research in hopes to conclude some type of evidence of the theories of SP, Old Hag Syndrome, and other ideas that R and I have been posting about.

The study per week will include:
•15 hours of research including blog posts with information of what was studied.
•Yahoo Questions and Answers
•Readings of Books: DMT The Spirit Molecule, Inner Paths to Outer Space, The New Science of Dreaming Vol I, II, III.
•Final Project: Power Point/ Paper

I will start this Christmas break by reading Dr. Strassman book "DMT - The Spirit Molecule" and do some research into the effects of DMT.

Anyways expect more posts in the near future as the research continues!

-L

Dream Study

So my proposal for a dream study was accepted by the psychology department adviser for this upcoming semester. It should be interesting and full of new research in hopes to conclude some type of evidence of the theories of SP, Old Hag Syndrome, and other ideas that R and I have been posting about.

The study per week will include:
•15 hours of research including blog posts with information of what was studied.
•Yahoo Questions and Answers
•Readings of Books: DMT The Spirit Molecule, Inner Paths to Outer Space, The New Science of Dreaming Vol I, II, III.
•Final Project: Power Point/ Paper

I will start this Christmas break by reading Dr. Strassman book "DMT - The Spirit Molecule" and do some research into the effects of DMT.

Anyways expect more posts in the near future as the research continues!

-L

Dream Study

So my proposal for a dream study was accepted by the psychology department adviser for this upcoming semester. It should be interesting and full of new research in hopes to conclude some type of evidence of the theories of SP, Old Hag Syndrome, and other ideas that R and I have been posting about.

The study per week will include:
•15 hours of research including blog posts with information of what was studied.
•Yahoo Questions and Answers
•Readings of Books: DMT The Spirit Molecule, Inner Paths to Outer Space, The New Science of Dreaming Vol I, II, III.
•Final Project: Power Point/ Paper

I will start this Christmas break by reading Dr. Strassman book "DMT - The Spirit Molecule" and do some research into the effects of DMT.

Anyways expect more posts in the near future as the research continues!

-L

Dream Study

So my proposal for a dream study was accepted by the psychology department adviser for this upcoming semester. It should be interesting and full of new research in hopes to conclude some type of evidence of the theories of SP, Old Hag Syndrome, and other ideas that R and I have been posting about.

The study per week will include:
•15 hours of research including blog posts with information of what was studied.
•Yahoo Questions and Answers
•Readings of Books: DMT The Spirit Molecule, Inner Paths to Outer Space, The New Science of Dreaming Vol I, II, III.
•Final Project: Power Point/ Paper

I will start this Christmas break by reading Dr. Strassman book "DMT - The Spirit Molecule" and do some research into the effects of DMT.

Anyways expect more posts in the near future as the research continues!

-L

Thursday, December 4, 2008

Possible Onirogens?

Some interesting plants that might be worth researching in relation to dreaming/lucid dreaming include: mugwort, damiana, valerian, khat, calea zacatechichi, wild lettuce, passion flower, yohimbe, ephedra, clary sage, salvia divinorum, hops, kava kava and many more.

There is a particular paperback on the subject titled Drugs of the Dreaming: Oneirogens: Salvia divinorum and Other Dream-Enhancing Plants by Gianluca Toro and Benjamin Thomas. However, I found it particularly lacking. There is certainly oodles of information in relation to dreaming and plant substances. However, I have yet to see it in satisfactory book form.

In addition to simply taking a substance, there is the issue of when a substance is taken and under what circumstances. In the case of a more stimulating plant, one possible route is for an individual to only engage in the practice after four hours of deep sleep. This may allow the said individual to be tired enough to fall back asleep while the stimulant slowly started working its effects. However, if one partook of the plant simply before bed, then one might not be able to sleep at all until the effects wore off. By that point, one’s body might be so exhausted that any chance of lucidity would be dreadfully cut short.

In other words, finding a correct plant substance that facilitates lucid dreaming is not as simple as ingesting a pill and expecting results. Not only that, but every individual’s chemical makeup ensures that different plants will not affect everyone in the same manner. Nonetheless, it is certainly an interesting topic and one that warrants further investigation.


-R

Possible Onirogens?

Some interesting plants that might be worth researching in relation to dreaming/lucid dreaming include: mugwort, damiana, valerian, khat, calea zacatechichi, wild lettuce, passion flower, yohimbe, ephedra, clary sage, salvia divinorum, hops, kava kava and many more.

There is a particular paperback on the subject titled Drugs of the Dreaming: Oneirogens: Salvia divinorum and Other Dream-Enhancing Plants by Gianluca Toro and Benjamin Thomas. However, I found it particularly lacking. There is certainly oodles of information in relation to dreaming and plant substances. However, I have yet to see it in satisfactory book form.

In addition to simply taking a substance, there is the issue of when a substance is taken and under what circumstances. In the case of a more stimulating plant, one possible route is for an individual to only engage in the practice after four hours of deep sleep. This may allow the said individual to be tired enough to fall back asleep while the stimulant slowly started working its effects. However, if one partook of the plant simply before bed, then one might not be able to sleep at all until the effects wore off. By that point, one’s body might be so exhausted that any chance of lucidity would be dreadfully cut short.

In other words, finding a correct plant substance that facilitates lucid dreaming is not as simple as ingesting a pill and expecting results. Not only that, but every individual’s chemical makeup ensures that different plants will not affect everyone in the same manner. Nonetheless, it is certainly an interesting topic and one that warrants further investigation.


-R

Possible Onirogens?

Some interesting plants that might be worth researching in relation to dreaming/lucid dreaming include: mugwort, damiana, valerian, khat, calea zacatechichi, wild lettuce, passion flower, yohimbe, ephedra, clary sage, salvia divinorum, hops, kava kava and many more.

There is a particular paperback on the subject titled Drugs of the Dreaming: Oneirogens: Salvia divinorum and Other Dream-Enhancing Plants by Gianluca Toro and Benjamin Thomas. However, I found it particularly lacking. There is certainly oodles of information in relation to dreaming and plant substances. However, I have yet to see it in satisfactory book form.

In addition to simply taking a substance, there is the issue of when a substance is taken and under what circumstances. In the case of a more stimulating plant, one possible route is for an individual to only engage in the practice after four hours of deep sleep. This may allow the said individual to be tired enough to fall back asleep while the stimulant slowly started working its effects. However, if one partook of the plant simply before bed, then one might not be able to sleep at all until the effects wore off. By that point, one’s body might be so exhausted that any chance of lucidity would be dreadfully cut short.

In other words, finding a correct plant substance that facilitates lucid dreaming is not as simple as ingesting a pill and expecting results. Not only that, but every individual’s chemical makeup ensures that different plants will not affect everyone in the same manner. Nonetheless, it is certainly an interesting topic and one that warrants further investigation.


-R

Possible Onirogens?

Some interesting plants that might be worth researching in relation to dreaming/lucid dreaming include: mugwort, damiana, valerian, khat, calea zacatechichi, wild lettuce, passion flower, yohimbe, ephedra, clary sage, salvia divinorum, hops, kava kava and many more.

There is a particular paperback on the subject titled Drugs of the Dreaming: Oneirogens: Salvia divinorum and Other Dream-Enhancing Plants by Gianluca Toro and Benjamin Thomas. However, I found it particularly lacking. There is certainly oodles of information in relation to dreaming and plant substances. However, I have yet to see it in satisfactory book form.

In addition to simply taking a substance, there is the issue of when a substance is taken and under what circumstances. In the case of a more stimulating plant, one possible route is for an individual to only engage in the practice after four hours of deep sleep. This may allow the said individual to be tired enough to fall back asleep while the stimulant slowly started working its effects. However, if one partook of the plant simply before bed, then one might not be able to sleep at all until the effects wore off. By that point, one’s body might be so exhausted that any chance of lucidity would be dreadfully cut short.

In other words, finding a correct plant substance that facilitates lucid dreaming is not as simple as ingesting a pill and expecting results. Not only that, but every individual’s chemical makeup ensures that different plants will not affect everyone in the same manner. Nonetheless, it is certainly an interesting topic and one that warrants further investigation.


-R

Wednesday, December 3, 2008

Sleep Paralysis

I wanted to post a little research I have conducted from the past about Sleep Paralysis (SP) and its relation to some ideas of Egyptian and other related beliefs.

Sleep Paralysis:
Sleep paralysis is a common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has duration of seconds to minutes.
The incidence of isolated sleep paralysis was, as per previous reports, higher in African-Americans.

(Reference: http://www.ncbi.nlm.nih.gov/pubmed/12211324)

Paralysis: this occurs after waking up or shortly before falling asleep. The person cannot move any body part, cannot speak, and only has minimal control over blinking and breathing. This paralysis is the same paralysis that occurs when dreaming. The brain paralyzes the muscles to prevent possible injury during dreams, as some body parts may move during dreaming. If the person wakes up suddenly, the brain may still think that it is dreaming, and sustains the paralysis.

Hallucinations:
Images or speaking that appear during the paralysis. The person may think that someone is standing beside them or they may hear strange sounds. These may be dreamlike, possibly causing the person to think that they are still dreaming. Often it is reported as feeling a weight on one's chest, as if being underneath a person or heavy object.

Physiologically, it is closely related to the paralysis that occurs as a natural part of REM (rapid eye movement) sleep, which is known as REM atonia. Sleep paralysis occurs when the brain awakes from a REM state, but the bodily paralysis persists. This leaves the person fully conscious, but unable to move. In addition, the state may be accompanied by terrifying hallucinations (hypnopompic or hypnagogic) and an acute sense of danger.

Humming, roaring, hissing, rushing and buzzing noises are frequent in conjunction with sleep paralysis (SP). This happens when the REM atonia sets in sooner than usual, before the person is fully asleep, or persists longer than usual, after the person has (in other respects) fully awoken.[30] SP is reportedly very frequent among narcoleptics. It occurs frequently in about 6% of the rest of the population, and occurs occasionally in 60%.[31] In surveys from Canada, China, England, Japan and Nigeria, 20 to 60% of individuals reported having experienced SP at least once in their lifetime.[32][33] The paralysis itself is frequently accompanied by additional phenomena. Typical examples include a feeling of being crushed or suffocated, electric ‘tingles’ or ‘vibrations’, imagined speech and other noises, the imagined presence of a visible or invisible entity, and sometimes intense emotion: fear or euphoria and orgasmic feelings.[34][35] SP has been proposed as an explanation for at least some alien abduction experiences.[36]
(Reference: http://www.csicop.org/si/9805/abduction.html)

Hypnagogic state:
States of awareness may be distinguished from the dream experiences typically reported; these include dreamlike states experienced as a person falls asleep and as he awakens, respectively called hypnagogic and hypnopompic reveries. During sleep itself there are nightmares, observable signs of sexual activity, and sleepwalking. Even people who ostensibly are awake may show evidence of such...
hallucinations ( in hallucination: Hypnagogic hallucinations )
Common hypnagogic hallucinations may be visual (e.g., scenes from the previous few hours appear) or auditory (e.g., one seems to hear one’s name called). A frequently occurring hypnagogic hallucination is the sensation of loss of support or balance, perhaps accompanied by a fragmentary “dream” of falling, followed immediately by a jerking reflex recovery movement

Theosophical Society Relation to Sleep Paralysis as the "Dweller of the Threshold"
The Guardian of the Threshold is a menacing figure that is described by a number of leading esoteric teachers, [1] [2] [3] The term "Guardian of the Threshold", often called "dweller on the threshold" indicates a spectral image which is supposed to manifests itself as soon as "the student of the spirit ascends upon the path into the higher worlds of knowledge"
According to Max Heindel, the Dweller on the Threshold (also called Guardian of the Threshold), which every aspirant has to meet -usually at an early stage of his progress into the unseen worlds- is one of the causes of main causes of obsession of men interested in occultism.

"This Dweller of the Threshold meets us in many shapes. It is the Cerberus guarding the entrance to Hades; the Dragon which St. Michael (spiritual will-power) is going to kill; the Snake which tempted Eve, and whose head will be crushed by the heel of the woman; the Hobgoblin watching the place where the treasure is buried, etc. He is the king of evil, who will not permit that within his kingdom a child should grow up, which might surpass him in power; the Herod before whose wrath the divine child Christ has to flee into a foreign country, and is not permitted to return to his home (the soul) until the king (Ambition, Pride, Vanity, Self-righteousness, etc.) is dethroned or dead."

(Reference: http://www.theosophical.ca/DwellerThresholdFH.htm)

Ethiopian Culture Relation to Sleep Paralysis as "Dukak"
In Ethiopian culture the word Dukak is used. Dukak is believed to be some form of evil spirit that possesses people during their sleep. This experience is also believed to be related to use of Khat. Khat chimical make up includes Norepinephrine which is a precursor to Dopamine. Neropinehrin supports and prolongs REM sleep and supports similar results as acetylcholine precursors.


Egyptian Relation to Sleep Paralysis as "Apep"
On the occasions when Apep was said to have been killed, he was able to return each night.
Apep was not so much worshipped, as worshipped against. His defeat each night, in favour of Ra, was thought to be ensured by the prayers of the Egyptian priests and worshipers at temples. The Egyptians practiced a number of rituals and superstitions that were thought to ward off Apep, and aid Ra to continue his journey across the sky.


Scandinavian Folklore Relation to Sleep Paralysis as the "Mara"
Mare is a kind of malignant female wraith in Scandinavian folklore believed to cause nightmares
The mara was thought of as an immaterial being – capable of moving through a keyhole or the opening under a door – who seated herself at the chest of a sleeping person and "rode" him or her, thus causing nightmares. The word nightmare is a compositon of the word Mara and Night.

Brittish and Anglophone North American folklore Relation to Sleep Paralysis as the "Old Hag"
According to folklore, the Old Hag sat on a sleeper's chest and sent nightmares to him or her. When the subject awoke, he or she would be unable to breathe or even move for a short period of time.


Neurobiology Relation to Sleep Paralysis as the "Old Hag Syndrom"
The expression Old Hag Attack refers to a hypnagogic state in which paralysis is present and, quite often, it is accompanied by terrifying hallucinations. When excessively recurrent, some consider them to be a disorder; however many populations treat them as simply part of their culture and mythological world-view, rather than any form of disease or pathology.


Night Terrors:
Night terrors happen during deep non-REM sleep. Unlike n
ightmares (which occur during REM sleep), a night terror is not technically a dream, but more like a sudden reaction of fear that happens during the transition from one sleep phase to another.

Night terrors typically occur about 2 or 3 hours after a child falls asleep, when sleep transitions from the deepest stage of non-REM sleep to lighter REM sleep, a stage where dreams occur. Usually this transition is a smooth one. But rarely, a child becomes agitated and frightened — and that fear reaction is a night terror.


Conclusion of Sleep Paralysis:
As anyone can see there has been a long history of hallucinations and SP relations during sleep stages in human history. There is a strong correlation to religiouse belifes of demons or other type of spherical encounters that can be easily explained by the occurrences of non dream state type hallucinations. In the relation to sleep paralysis, it can be concluded from the historical evidence of SP that SP can contain both hallucinations with and without the paralysis.
Since SP is related to the hypnagogic state of mind, then the hallucinations most likely are caused by the hypnagogic states of mind rather than the SP itself. Since hypnagogic state of mind is present in non-REM status as well as moving from REM to other sleep stages, SP and hypnogogia type of hallucinations can be related to non-REM to REM transitions. Night Terrors are also experienced during this non-REM transition as well as deep sleep. With this relation, NT has a strong correlation as being the same hypnogogic hallucination as experienced during SP. Nightmares are also hypnogogic hallucinations since the word nightmare is composed from the Scandinavian Folklore word "Mara."

Wake Induced Lucid Dreaming (WILD) shows the same type of hallucinations during the conscious transition from waking states to dreaming.

**I need to research more about drugs and their relation to hypnogogic states of hallucinations.




-L

Sleep Paralysis

I wanted to post a little research I have conducted from the past about Sleep Paralysis (SP) and its relation to some ideas of Egyptian and other related beliefs.

Sleep Paralysis:
Sleep paralysis is a common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has duration of seconds to minutes.
The incidence of isolated sleep paralysis was, as per previous reports, higher in African-Americans.

(Reference: http://www.ncbi.nlm.nih.gov/pubmed/12211324)

Paralysis: this occurs after waking up or shortly before falling asleep. The person cannot move any body part, cannot speak, and only has minimal control over blinking and breathing. This paralysis is the same paralysis that occurs when dreaming. The brain paralyzes the muscles to prevent possible injury during dreams, as some body parts may move during dreaming. If the person wakes up suddenly, the brain may still think that it is dreaming, and sustains the paralysis.

Hallucinations:
Images or speaking that appear during the paralysis. The person may think that someone is standing beside them or they may hear strange sounds. These may be dreamlike, possibly causing the person to think that they are still dreaming. Often it is reported as feeling a weight on one's chest, as if being underneath a person or heavy object.

Physiologically, it is closely related to the paralysis that occurs as a natural part of REM (rapid eye movement) sleep, which is known as REM atonia. Sleep paralysis occurs when the brain awakes from a REM state, but the bodily paralysis persists. This leaves the person fully conscious, but unable to move. In addition, the state may be accompanied by terrifying hallucinations (hypnopompic or hypnagogic) and an acute sense of danger.

Humming, roaring, hissing, rushing and buzzing noises are frequent in conjunction with sleep paralysis (SP). This happens when the REM atonia sets in sooner than usual, before the person is fully asleep, or persists longer than usual, after the person has (in other respects) fully awoken.[30] SP is reportedly very frequent among narcoleptics. It occurs frequently in about 6% of the rest of the population, and occurs occasionally in 60%.[31] In surveys from Canada, China, England, Japan and Nigeria, 20 to 60% of individuals reported having experienced SP at least once in their lifetime.[32][33] The paralysis itself is frequently accompanied by additional phenomena. Typical examples include a feeling of being crushed or suffocated, electric ‘tingles’ or ‘vibrations’, imagined speech and other noises, the imagined presence of a visible or invisible entity, and sometimes intense emotion: fear or euphoria and orgasmic feelings.[34][35] SP has been proposed as an explanation for at least some alien abduction experiences.[36]
(Reference: http://www.csicop.org/si/9805/abduction.html)

Hypnagogic state:
States of awareness may be distinguished from the dream experiences typically reported; these include dreamlike states experienced as a person falls asleep and as he awakens, respectively called hypnagogic and hypnopompic reveries. During sleep itself there are nightmares, observable signs of sexual activity, and sleepwalking. Even people who ostensibly are awake may show evidence of such...
hallucinations ( in hallucination: Hypnagogic hallucinations )
Common hypnagogic hallucinations may be visual (e.g., scenes from the previous few hours appear) or auditory (e.g., one seems to hear one’s name called). A frequently occurring hypnagogic hallucination is the sensation of loss of support or balance, perhaps accompanied by a fragmentary “dream” of falling, followed immediately by a jerking reflex recovery movement

Theosophical Society Relation to Sleep Paralysis as the "Dweller of the Threshold"
The Guardian of the Threshold is a menacing figure that is described by a number of leading esoteric teachers, [1] [2] [3] The term "Guardian of the Threshold", often called "dweller on the threshold" indicates a spectral image which is supposed to manifests itself as soon as "the student of the spirit ascends upon the path into the higher worlds of knowledge"
According to Max Heindel, the Dweller on the Threshold (also called Guardian of the Threshold), which every aspirant has to meet -usually at an early stage of his progress into the unseen worlds- is one of the causes of main causes of obsession of men interested in occultism.

"This Dweller of the Threshold meets us in many shapes. It is the Cerberus guarding the entrance to Hades; the Dragon which St. Michael (spiritual will-power) is going to kill; the Snake which tempted Eve, and whose head will be crushed by the heel of the woman; the Hobgoblin watching the place where the treasure is buried, etc. He is the king of evil, who will not permit that within his kingdom a child should grow up, which might surpass him in power; the Herod before whose wrath the divine child Christ has to flee into a foreign country, and is not permitted to return to his home (the soul) until the king (Ambition, Pride, Vanity, Self-righteousness, etc.) is dethroned or dead."

(Reference: http://www.theosophical.ca/DwellerThresholdFH.htm)

Ethiopian Culture Relation to Sleep Paralysis as "Dukak"
In Ethiopian culture the word Dukak is used. Dukak is believed to be some form of evil spirit that possesses people during their sleep. This experience is also believed to be related to use of Khat. Khat chimical make up includes Norepinephrine which is a precursor to Dopamine. Neropinehrin supports and prolongs REM sleep and supports similar results as acetylcholine precursors.


Egyptian Relation to Sleep Paralysis as "Apep"
On the occasions when Apep was said to have been killed, he was able to return each night.
Apep was not so much worshipped, as worshipped against. His defeat each night, in favour of Ra, was thought to be ensured by the prayers of the Egyptian priests and worshipers at temples. The Egyptians practiced a number of rituals and superstitions that were thought to ward off Apep, and aid Ra to continue his journey across the sky.


Scandinavian Folklore Relation to Sleep Paralysis as the "Mara"
Mare is a kind of malignant female wraith in Scandinavian folklore believed to cause nightmares
The mara was thought of as an immaterial being – capable of moving through a keyhole or the opening under a door – who seated herself at the chest of a sleeping person and "rode" him or her, thus causing nightmares. The word nightmare is a compositon of the word Mara and Night.

Brittish and Anglophone North American folklore Relation to Sleep Paralysis as the "Old Hag"
According to folklore, the Old Hag sat on a sleeper's chest and sent nightmares to him or her. When the subject awoke, he or she would be unable to breathe or even move for a short period of time.


Neurobiology Relation to Sleep Paralysis as the "Old Hag Syndrom"
The expression Old Hag Attack refers to a hypnagogic state in which paralysis is present and, quite often, it is accompanied by terrifying hallucinations. When excessively recurrent, some consider them to be a disorder; however many populations treat them as simply part of their culture and mythological world-view, rather than any form of disease or pathology.


Night Terrors:
Night terrors happen during deep non-REM sleep. Unlike n
ightmares (which occur during REM sleep), a night terror is not technically a dream, but more like a sudden reaction of fear that happens during the transition from one sleep phase to another.

Night terrors typically occur about 2 or 3 hours after a child falls asleep, when sleep transitions from the deepest stage of non-REM sleep to lighter REM sleep, a stage where dreams occur. Usually this transition is a smooth one. But rarely, a child becomes agitated and frightened — and that fear reaction is a night terror.


Conclusion of Sleep Paralysis:
As anyone can see there has been a long history of hallucinations and SP relations during sleep stages in human history. There is a strong correlation to religiouse belifes of demons or other type of spherical encounters that can be easily explained by the occurrences of non dream state type hallucinations. In the relation to sleep paralysis, it can be concluded from the historical evidence of SP that SP can contain both hallucinations with and without the paralysis.
Since SP is related to the hypnagogic state of mind, then the hallucinations most likely are caused by the hypnagogic states of mind rather than the SP itself. Since hypnagogic state of mind is present in non-REM status as well as moving from REM to other sleep stages, SP and hypnogogia type of hallucinations can be related to non-REM to REM transitions. Night Terrors are also experienced during this non-REM transition as well as deep sleep. With this relation, NT has a strong correlation as being the same hypnogogic hallucination as experienced during SP. Nightmares are also hypnogogic hallucinations since the word nightmare is composed from the Scandinavian Folklore word "Mara."

Wake Induced Lucid Dreaming (WILD) shows the same type of hallucinations during the conscious transition from waking states to dreaming.

**I need to research more about drugs and their relation to hypnogogic states of hallucinations.




-L